The Funniest Big Bang Theory Characters, In Order

Sheldon: When do you evacuate your bowels?
Leonard: When I have to.
Sheldon: When you have to? I'm sorry, I don't rent to hippies.

Sheldon (duh - may be in the top 5 sitcom characters of all time pantheon, behind only Archie, George, and Alex P. Keaton. Favorite quote HERE.)
Howard (five-tool player)
Amy Farrah Fowler (can she just fucking roofee Penny already?)
Howard's mother (never seen onscreen, always on the shitter)
Sheldon's mother (aka Jackie from Roseanne, Jesus freak)
Bernadette (hysterical when she morphs into Howard's mother)
Raj
Penny
Leonard (aka David from Roseanne. Rarely funny.)
Darlene from Roseanne (too fugly to be funny)